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Future studies could focus on elucidating the specific mechanisms by which PHGDH regulates immune responses within the TME, thereby developing more effective combination therapeutic strategies

Hydrogel-based biomaterials have emerged as a disruptive innovation capable of addressing these limitations [20]

On the other hand, the current results disagree with the study of Manggabarani and colleagues , who observed statistically significant skin brightness in patients who used a combination of topical glutathione 2%, tocopheryl acetate 1%, and 3% magnesium ascorbyl phosphate

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