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Contraindications Otezla/OTEZLA XR is contraindicated in patients with a known hypersensitivity to apremilast or to any of the excipients in the formulation Warnings and Precautions Hypersensitivity: Hypersensitivity reactions, including angioedema and anaphylaxis, have been reported during postmarketing surveillance

Measurement of cutaneous inflammationestimation of neutrophil content with an enzyme marker

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High oral doses are generally considered safe, though injectable B12 frequency should only be adjusted under medical supervision to ensure underlying causes of symptoms are properly investigated