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It's even linked to higher pregnancy rates 12

As cell mass continues to decrease, the increased metabolic demand, continuous exposure to pro-inflammatory cytokines, and sustained hyperglycemic conditions upregulate mitochondrial and ER stress in cells, which further impair cell function and promote stress-mediated stress (179188)

In lesional skin, excessive accumulation of ROS compromises the epidermal barrier, facilitates TEWL and allergen penetration, activates pro-inflammatory signaling cascades, and disrupts immune homeostasis (Raimondo et al., 2023)

The answer, as we'll explore, largely depends on its state and intended duration of storage