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The primary reason for the lower quantity was that higher energy prices spurred conservation efforts, and after a decade of home insulation, more fuel-efficient cars, more efficient appliances and machinery, and other fuel-conserving choices, the demand curve for energy had become more elastic

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These signaling pathways include the TGF-/Smad signaling pathway, the Wnt/-catenin signaling pathway, PI3K-Akt signaling pathway, and NF-B signaling pathway, etc