54 In contrast, when animals were treated with tert-butylhydroperoxide to induce LPO-mediated liver injury, extensive LPOindicated by a 12- to 30-fold increase in these LPO parameterswas necessary to even cause moderate liver injury
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Emerging evidence suggests that the underlying pathophysiology involves oxidative stress, impaired autophagy, ferroptosis, protein post-translational modifications, chronic low-grade inflammation, and gut microbiota dysbiosis affecting ovarian, hepatic, and pancreatic tissues
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