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Identifying what a patient has already tried during their attempts to quit nicotine, as well as their mental and physical reactions to it, can help to determine what the next method of quitting can entail.[16] If one is trying to quit, it is important to recognize that the cessation process will require constant effort

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Increased CYP1A1 metabolism can cause the buildup of the intermediate metabolites if your body cant get rid of them fast enough through phase II metabolism