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"We believe that smoke-free alternatives, including heated tobacco products like IQOS and e-cigarettes, have significant potential to be less harmful than cigarettes and can play an important role for smokers and public health." Simon Clark from the smokers' group Forest said: "Electronic cigarettes are a step too far for many smokers so if the government wants smokers to quit there has to be a range of products that fills the gap between combustible tobacco and e-cigarettes."

The basic idea is that the barrier between the brain and the rest of the body degrades, which allows cholesterols and free fatty acids to invade the brain and cause damage