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Jamei M, Dickinson GL, Rostami-Hodjegan A (2009) A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: a tale of `Bottom-Up vs`Top-Down recognition of covariates

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Antihistamines like hydroxyzine and diphenhydramine are frequently employed as initial treatments for pruritus due to their safety and availability

While the results of this preliminary study conducted using a small sample size is not sufficient to generalize these benefits, our results emphasize the potential of this naturally occurring combination to be developed into a safe, effective therapeutic strategy to manage ADHD