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Metabolically, inadequate vitamin B12 status is associated with the accumulation of MMA, a specific functional marker of vitamin B12 deficiency (75)

It is worth noting that the relationship between cortical and striatal DA is bidirectional as evidenced by the finding that increased dorsal striatal dopaminergic signaling led to a reduction in mesocortical DA release while resulted in cognitive deficits [71, 72]

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