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Additionally, molecular analysis indicated that up-regulation of -arrestin2, an intracellular protein involved in the desensitization and internalization of dopamine receptors and activation of alternative signaling pathways, may be associated with reduced severity of dyskinesia in levodopa-benserazide-loaded PLGA nanocarrier-treated PD rats

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To conduct the study, 24 rats were randomly divided into four groups: quercetin supplementation, exercise, a combination of quercetin and exercise, and a control group, with six animals in each group