Blinded therapy was continued through 24 weeks, although nonresponders at 14 and 16 weeks were able to escape to active treatment
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Furthermore, to refine the experimentally determined structural model and explore interaction dynamics, we conducted extensive MD simulations
The peptide downregulates or inhibits key lipogenic enzymes including fatty acid synthase and acetyl-CoA carboxylase, which are responsible for converting excess dietary carbohydrates and other substrates into fatty acids for storage