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For Research Use Only: This product is strictly for laboratory research purposes and isnot for human or animal consumption

Bloodwork may be recommended to confirm

At the same time, damaged liver cells and infiltrating immune cells activate multiple enzyme systems including NADPH oxidase and cause explosive growth of ROS

Cuadrado and colleagues first showed that GSK-3 inhibits NRF2 activity, but the identification of sites in NRF2 that are phosphorylated by GSK-3 was achieved several years later using two-dimensional electrophoresis and mass spectrometry: GSK-3 phosphorylates a group of Ser residues at the level of DSGIS motif in the Neh6 domain of NRF2, and this event represents the signal for the recognition by the adapter protein -TrCP, that targets NRF2 for ubiquitination and proteasomal degradation in a KEAP1-independent manner [150, 151]