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While dietary interventions such as fasting regimens and surgical interventions like bariatric surgery constitute effective weight loss measures in combating the obesity epidemic 4,5 , they are largely insufficient to restore AT function in mice 6,7,8,9,10,11 and humans 11,12,13,14,15,16

By promoting mitochondrial dysfunction and increasing iron-dependent ROS levels, neratinib works synergistically with ferroptosis inducers like RSL3

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