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Folate supplementation must not be started before B12 deficiency is treated, as this can precipitate or worsen neurological complications

doi: 10.1016/j.neuron.2015.02.019 30 PironeAAlexanderJMKoenigJBCook-SnyderDRPalnatiMWickhamRJet al

A meta-analysis of six trials in participants with type 2 diabetes and one trial in participants with type 1 diabetes found that 100 to 200 mg/day of coenzyme Q 10 for three to six months lowered neither fasting plasma glucose nor levels of glycated hemoglobin ([HbA1c]

The record is not uniformly positive, and the biology is context-sensitive: the same peptide prolongs normal-cell survival yet stimulates neoplastic-cell growth, [1] and at least one in-vivo wound model reported delayed rather than accelerated repair