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In contrast, exposure of non-nicotinized E-smoke from flavor 2 on the bro-ALI resulted in decreased transcript expression of pro-inflammatory markers and increased anti-inflammatory marker whereas oxidative stress markers, anti-protease, alarm anti-proteases, and anti-microbial defense response markers were induced

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granulomas in alveolar spaces and adjacent interstitial areas of all lobes of the lung in F-344 rats