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Food and Drug Administration, et al

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Other factors that may increase the chances of developing smokers leg include: smoking being over the age of 60 years having overweight or obesity diabetes high blood pressure high cholesterol a family history of PAD, heart disease, or stroke chronic kidney disease or being on dialysis Many people with smokers leg experience no signs or symptoms

People with these conditions experience depressive episodes marked by deep sadness and fatigue, which occur alongside contrasting episodes of mania or hypomania