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Nasu, E

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Although several studies have demonstrated the efficacy of RSL3 in various animal models (31, 32), non-specific effects of RSL3 cannot be excluded given its poor bioavailability in vivo ( To date, the majority of studies regarding drug-tolerant persister cells have focused on persister cells from immortalized cell lines, demonstrating that they occur as a small subset of the total tumor population (33)

Dihexa operates through a singular, highly potent mechanism: it binds to the c-Met receptor (the hepatocyte growth factor receptor) and potentiates its response to endogenous HGF by stabilizing receptor-ligand interactions