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This suggests that NO and hydrogen peroxide produced by mtNOS act as diffusible toxohormones, promoting oxidative stress in nearby non-tumor tissues and thereby facilitating tumor progression

Lower levels are associated with reduced cellular energy, increased oxidative stress, and slower metabolic processes

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While important mechanistic insights were gained to decipher the glutaredoxin-catalyzed reduction of glutathione disulfide substrates, there are still major gaps in our understanding of the enzyme mechanism regarding the reduction of non-glutathione disulfide substrates