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This allows research protocols to utilize [Capsules] rather than injections, simplifying long-term administration studies in rodent models

Enlargement of the ring system of 23 , by oxidatative cyclization of Hcy 1 /Hcy 3 side chains rather than the Hcy 1 /Cys 3 side chains of 23 resulted in a compound comprising a 14-membered macrocycle but with a somewhat lower affinity to IRAP (Ki = 5.1 nM), vide infra

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Storage: Keep lyophilized vials in a cool, dark place (many labs prefer -20C )