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A study on metabolically healthy men found that 12-week synbiotic intervention significantly reduced serum alanine aminotransferase levels, with a 20.70% reduction in the subgroup with elevated body fat percentage, and significant changes in gut microbiome composition occurred in this subgroup, suggesting synbiotics may exert hepatoprotective effects on specific populations by regulating gut flora

It might be the coffee causing the reflux, and the collagen is simply the ingredient you added recently

866 Excitatory amino acid transporter 1(EAAT1) in senescent cartilage membranes can increase intracellular glutamate levels and activate the GSH synthesis system to combat ferroptosis

doi: 10.1002/hep4.1268, 42