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A simplified form of the reaction follows: Equation 2: X-Z + GS- GS-X + Z- Pumps that recognize the glutathione conjugated with a xenobiotic (Figure 21) (GS-X) have been described in animal plasmamembranes and plant tonoplast membranes

The higher level of GSSG observed in the serum of many children with autism spectrum disorders [4648, 50, 85, 87, 91] is likely to truly reflect increased oxidative stress as there is no significant difference in GPx-1 activity in serum or platelets [63, 84] and GPx-1 is significantly lower in the erythrocytes of children with autistic disorder compared to controls

Bhandari, R., Sharma, A

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