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Figure 2 There is also now ample evidence demonstrating that insulin reaching the liver via the portal system plays an important role in making the liver more GH sensitive to IGF-I generation ( Effects of disease states on intra-portal insulin levels and changes in the GH/IGF-I axis High GH and low IGF-I Type 1 diabetes is an autoimmune disease characterized by pancreatic -cell destruction leading to intra-portal hypoinsulinemia

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