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Additionally, they promote the release of cytokines, chemokines, and pro-inflammatory neuropeptides, thus being associated with peripheral neuroinflammation [12,45]

Tendon and joint healing typically takes longer, often the full four to eight week cycle before clear improvement shows up

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The therapeutic era of peptides began in 1921 with the discovery of insulin, a breakthrough that revolutionized diabetes and helped establish biologic therapies in medicine 1 Since then, peptide hormones like oxytocin and human growth hormone (GH) have entered clinical use, and glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide are now widely prescribed for obesity and metabolic diseaseconditions increasingly recognized for their effect on orthopaedic outcomes