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The math is not complicated once you understand the relationships, but a single miscalculation can lead to dramatically wrong doses

Finally, there are also data showing that even though serum IGF-I is acutely increased following prednisolone, this is not the case in lymph-like tissue fluid (107), suggesting that glucocorticoids exert distinct, compartment-specific effects on IGF-I action

However, -CG challenge increased ( P 4%, 10 days) or -CG (4%-8%, 3 days) can reduce average daily gain in piglets 19,21

It acts pleiotropically , the technical term for the fact that it activates multiple signaling pathways in the cell at once