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Chronic pain often involves nervous system sensitization, metabolic dysfunction, nutrient depletion, or low-grade inflammation that may not appear on standard imaging or routine laboratory tests

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In addition, pro-inflammatory M1-like macrophages in T2D mice were found to secrete exosomes containing the microRNA, miR-212-5p, that can be taken up by -cells, in turn inhibiting SIRT2-mediated Akt activation and subsequently impairment of glucose stimulated insulin secretion (74)

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