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In another work, the combination of cyclodextrin (CDs) with agar to render chemically cross-linked hydrogels with drugs by the formation of inclusion complexes or ionic bonds with polysaccharide enhanced loading ability, dually controlled delivery, release profile based on CD affinity and tunable external stimuli such as pH and ionic strength [171]

Its effects require intact amylin receptor signaling, as demonstrated in receptor knockout models where weight loss is abolished, and structural studies show unique conformational dynamics at these receptors compared to native amylin or other analogs

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