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Following GPX3 inhibition, tumor cells may proliferate, enhancing drug accumulation within the cells (73,77)

[DOI] [PMC free article] [PubMed] [Google Scholar] [24].Alam J, Camhi S, Choi AMK

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The cysteinyl sulfur of glutathione (GSH) is maintained in the reduced state by NADPH produced in the oxidative phase of the pentose phosphate shunt and provides a nucleophilic thiol important for the detoxification of electrophilic metabolites and metabolically-produced oxidizing agents