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But nicotine is highly addictive

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The findings may be due to two factors: the populations growth and ageing, which have intensified smoking and increased disease burden, and global anti-smoking initiatives over recent decades, such as price and tax controls, public smoking bans, public awareness campaigns about tobacco risks, and enhanced global cooperation, as outlined in the WHO Framework Convention on Tobacco Control (FCTC) 8-11

Therefore, less activity in DLPFC reduces these cognitive operations, making relapse more likely. People in the relapse group also had reduced suppression of activation in the posterior cingulate cortex (PCC), a central part of the brains default mode network, which is active when a person is not focused on a specific task