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Figure 2 Mechanistically, nicotine activates AMPK2 in adipocytes, which phosphorylates MAP kinase phosphatase-1 (MKP1) at serine 334, resulting its proteasome-dependent degradation ( 2 -terminal kinase (JNK), which phosphorylates insulin receptor substrate 1 (IRS1) at serine 307

Figure 4 explores perceived health risks associated with tobacco products and e-cigarettes

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Such strategies already are at work in Missouri, where big tobacco and smaller cigarette manufacturers are squaring off over two potential November ballot proposals