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4.1.2 PI3K/AKT inhibitors Activation of phosphoinositide 3-kinase (PI3K) can lead to the phosphorylation and subsequent inactivation of Bad and caspase-9 [111]

Expectedly, depletion of cystine or inhibition of the Xc- antiporter using synthetic small molecule inhibitors including erastin, sulfasalazine, sorafenib and even excess of glutamate triggered cystine depletion, decreased GSH level and reduced GPX4 activity, culminating in ferroptosis induction

Alkohol fhrt zu einer Senkung des Glutathion-Spiegels

Conversely, in another study, SOD activity has been found to be lower in epilepsy patients than in healthy individuals 22