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The expression of COX-IV, a subunit of COX translocation protons, was high not only in ductal epithelial cells in the control group but also in the immune cells of lymphoid infiltrating lesions in the pSS group ( Figure 6B )

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In some of such embodiments, a low viscosity otic formulation or device is administered in combination with an external otic intervention, e.g., a surgical procedure including but not limited to middle ear surgery, inner ear surgery, typanostomy, cochleostomy, labyrinthotomy, mastoidectomy, stapedectomy, stapedotomy, endolymphatic sacculotomy, or the like