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It also plays an important role in maintaining proper immune function

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10.1038/s41418-018-0179-3 77 KimS

It was found that under energy deficiency, PFKFB3 is phosphorylated at residue S461 by AMP-activated kinase (AMPK), and that this phosphorylation increases the activity of PFKFB3, stimulating glycolysis and ATP production (110)