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Furthermore, SFN orchestrates a multi-pronged assault on cancer cells by promoting the acetylation of non-histone proteins such as p53, and synergistically activating critical pathways including cell cycle arrest, apoptosis, and sensitization to other therapeutic agents like TRAIL, which is particularly promising for targeting therapy-resistant cases (66)

While the incidence of adverse events is high, the severity varies, with only a small percentage of patients experiencing serious side effects, explains Jeffrey A

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