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Tobacco does not show a safety threshold12,13 and respiratory and cardiovascular abnormalities could be related to HTP exposure.14,15 We could speculate that smokers who inhale IQOS, even if they received less exposure, will suffer similar consequences to those who smoke a single CC per day and who have also reported serious damage to their health, such as an increased risk of cardiac disease by 74% and stroke by 30% in men and even worse in women, 119% and 46% respectively if confounding factors are considered.16 Future research should focus on cardiovascular, pulmonary, and systemic inflammatory events17 and focus on hard-to-see smoke and its possible equivalence to second- and even third-hand smoke