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While it seems that drug exposure does not account for the greater deficit of ACC glutamate in the Established group, an influence of antipsychotic drug exposure on glutamate neurotransmission via glutamine cannot be ruled out

And they do happen

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doi: 10.1111/j.20427158.1970.tb08465.x 237 HolmgrenSAxelssonMJensenJAldmanGSundellKJonssonAC