With the exception of relugolix combined tablet, their use presents the risks of side-effects associated with GnRH agonists/antagonists (hot flashes, sleep disturbances, vaginal dryness, depression and loss of bone mass) and clinical recommendations encourage the use of add-back therapies to mitigate them, such as tibolone
They are listed with injections because they are injectable services, but they require separate eligibility review, labs, follow-up, and medical oversight
By influencing pineal-related signaling described in scientific literature, it may help some users fall asleep more easily, wake more consistently, and feel less out of sync after schedule changes
Further studies are therefore warranted to better understand the role of NRP1 + ILC3 in endothelial cell activation and to eventually extend this to cancer