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They support earlier studies that came to similar conclusions based on smaller numbers of observed individuals

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It is erroneous to assume that tolerance and dependence, the strongest predictors of addiction, stem only from chronic substance use, according to a 1987 article by Miller et al., published in the Journal of Substance Abuse Treatment , titled The relationship of addiction, tolerance, and dependence to alcohol and drugs: a neurochemical approach . Studies have shown tolerance to alcohol and other drugs developing within hours and days of taking a single dose

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