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KPV's anti-inflammatory contribution is relevant here: synovial inflammation is a consistent feature of chronic joint stress models, and the reduction of IL-1 and TNF- that KPV demonstrates in cell culture models would be a logical correlate in a joint-stress research context [7]

The sampling source (serum or plasma) did not address the heterogeneities, whereas stratifications base on unevenly distributed age and sex ratio between the ASD and HC groups revealed different between-study heterogeneities for several subgroups, indicating potential moderating effects of age and sex on the meta-analysis outcome