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There is growing evidence that the microbiome may be critical for establishing, maintaining, and reversing obesity 14,15,16 , and that both diet composition and adiposity each contribute to modulation of the mouse gut microbiome profile 49

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In the future, the regulatory field around peptides may partly mirror the regulation of dietary supplements: they are regulated, but their safety must be supported by evidence of no harm, and promises about outcomes must be realistic and tightly tied to available data