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Moreover, the use of antioxidants has been explored as a potential therapeutic strategy to mitigate oxidative stress in thalassemia patients

Interestingly, the presence of a molecule of structural NADP, which had been suggested by early biochemical work, has been confirmed

Additionally, existing ferroptosis inducers suffer from off-target toxicity and poor tumor penetration, which are further aggravated by the physical barriers and metabolic properties of the TME (65)

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