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These changes to the microenvironment can lead to adverse side effects as well as long-term damage which continues to have a detrimental impact on the patients quality of life, even after remission

Accessed 7 Sept 2025 Phaniendra A, Jestadi DB, Periyasamy L (2015) Free radicals: properties, sources, targets, and their implication in various diseases

It represents the primary cause of pain, functional impairment, and long-term disability among middle-aged and elderly individuals globally ( Photobiomodulation therapy (PBMT), also known as low-level laser therapy (LLLT), has demonstrated unique potential as a non-pharmacological, extracorporeal photobiomodulation (PBM) treatment modality in the management of KOA ( Nevertheless, the clinical application of PBMT in KOA remains controversial, with its heterogeneous efficacy drawing considerable attention