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For example, initial T cells have the lowest metabolic efficiency for glutamine metabolism because they only require it for survival, while effector T cells (Teff) that require rapid proliferation have a higher rate of glutamine metabolism, providing them with sufficient macromolecular synthesis materials

however, the association has negative predictive value (NPV) significantly less than 100%, particularly in non-East-Asian populations where the association is not as strong [41]

Wolfson, R.L., et al.,Sestrin2 is a leucine sensor for the mTORC1 pathway