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Outcome indicators: studies reporting any association related to the pathway nutrients [e.g., dietary fiber, omega-3 polyunsaturated fatty acids (PUFAs)] intestinal inflammation depression, including but not limited to intestinal inflammation markers [e.g., interleukin-6 (IL-6), Tumor necrosis factor- (TNF-)], depression assessment scores [e.g., Beck Depression Inventory-II (BDI-II), Patient Health Questionnaire-9 (PHQ-9)], and changes in gut microbiota composition

However, given the known autocrine/paracrine actions of IGF-1, local manipulation of IGF-1 expression and secretion by muscle fibres may not only be safer but also more effective (Fig

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