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doi: 10.3389/fimmu.2026.1794782 Received 23 January 2026 Revised 17 February 2026 Accepted 20 February 2026 Published 05 March 2026 Volume 17 - 2026 Edited by Robson Coutinho-Silva, Federal University of Rio de Janeiro, Brazil Reviewed by Bingbing Sun, Dalian University of Technology, China Hui-chen Lo, Fu Jen Catholic University Libraries, Taiwan Updates Copyright 2026 Yang, Xu, Zhang, Xiao, Lu, Chen, Yang, Xie and Li

If you experience discomfort, discontinue use

As theyre both active ingredients, try using them at different times of day to reduce the possibility for irritation or side effects

It is important that a beta-blocker is administered only after blockade of vascular alpha-adrenoceptors so that a hypertensive crisis does not occur because of unopposed alpha-adrenoceptor stimulation