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Impaired central nervous system regulation following insult to the spinal cord leads to abnormal signaling in peripheral nerves that innervate skeletal muscle, resulting in skeletal muscle atrophy [6, 7]
MGF and Muscle Repair Contradictory Data A study by two pharmaceutical companies attempting to reproduce claimed satellite cell proliferation effects found that concentrations of MGF peptide up to 500 ng/ml failed to increase the proliferation of C2C12 cells or primary human skeletal muscle myoblasts while all cell types exhibited a proliferative response to mature IGF-1 or full-length IGF-1Eb calling into question whether discrete MGF peptide has a physiological role in this process and highlighting the importance of cell type, model system, and peptide formulation in MGF research design
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Overdose No cases of overdosage have been reported in the literature
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