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To account for the continuing degeneration and atrophy in later stages, in the face of waning adaptive inflammation as the disease progresses, it has been proposed that the inflammation becomes trapped behind the bloodbrain barrier, continuing to damage the CNS, but now being inaccessible to peripherally-administered immunosuppressants

In summary, PEFs transform cold tumors into immune-permissive states ( 6 Prospects PEFs offers significant advantages in tumor therapy, positioning it as a promising tool for both treatment and research ( Table 2 )

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B12 is indispensable for a healthy immune system due to its involvement in critical functions