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The compound was developed by Peter de Keizer and colleagues at Erasmus University Medical Center (Rotterdam) and published in a landmark 2017 Cell paper (Baar et al., Cell 169:132-147) demonstrating selective induction of apoptosis in cellular senescence research models

Different forms of ER stress in chondrocytes result in short stature disorders and degenerative cartilage diseases: new insights by cartilage-Specific ERp57 knockout mice