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Generative AI statement The author(s) declare that no Generative AI was used in the creation of this manuscript

In a 2001 study published in Endocrinology , Heffernan and colleagues reported that chronic AOD-9604 administration reduced body weight gain, decreased adipose tissue mass, and increased fat oxidation in obese mice without altering IGF-1 levels or glucose metabolism effects that were abolished in beta3 adrenergic receptor (3-AR) knockout mice, implicating 3-AR signaling as the mechanism of action [1]

The overall risk appears to be very low, but the theoretical concern necessitates appropriate patient selection and informed consent

Some patients may begin with weekly injections to establish steady nutrient levels, while others transition to biweekly or monthly treatments once those levels are stabilized