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The pharmacokinetic parameters in this study were as follows: maximum plasma concentration (C max ), time to reach the maximum plasma concentration (T max ), area under the plasma concentrationtime curve from 0 to 72 h (AUC 0-72 ), area under the plasma concentrationtime curve from time 0infinity, absolute bioavailability, accumulation ratio, mean residence time (MRT), volume of distribution (Vd), total clearance (CL), and elimination half-life

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