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In penetrating injuries, the object penetrates both the skull and the dura, resulting in direct injury to the brain, while in closed-head injuries, the skull and dura remain intact

Similarly, acalabrutinib (AP-196), a third-generation BTK inhibitor in combination with anti-PD-1 therapy in a Phase II trial (NCT02362048), displayed sustained and selective reduction in PMN-MDSCs while sparing M-MDSCs (107)